Abstract
Norepinephrine and serotonin play an important role in a wide variety of biological processes and are implicated in a number of neurological disorders. A novel class of 1-(3-amino-1-phenylpropyl)indolin-2-ones was designed and synthesized that displays potent norepinephrine reuptake inhibition while maintaining high selectivity (>100-fold) against the human serotonin and dopamine transporters.
MeSH terms
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Humans
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Indoles / chemical synthesis*
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Indoles / chemistry
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Indoles / pharmacology*
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Molecular Structure
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Neurotransmitter Uptake Inhibitors / chemical synthesis*
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Neurotransmitter Uptake Inhibitors / chemistry
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Neurotransmitter Uptake Inhibitors / pharmacology*
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Norepinephrine / antagonists & inhibitors*
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Stereoisomerism
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Structure-Activity Relationship
Substances
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Indoles
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Neurotransmitter Uptake Inhibitors
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indolin-2-one
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Norepinephrine